From South Park — S12E01 “Tonsil Trouble”…
Kyle: “What part of being infected with a deadly disease do you find funny?”
Cartman: “I don’t think it’s funny.”
Kyle: “Then stop saying you’re not just sure, you’re HIV-positive.
This isn’t funny, AIDS isn’t funny, dying isn’t funny, so shut the **** up.”
Cartman: “Well, excuse me Kyle for trying to keep some optimism. Sometimes when things seem their darkest you need to try and stay HIV-positive. But if you want to be so HIV-negative all the time.”
Kyle: “Knock it off, right now! This isn’t funny! At all”
Cartman: “Are you sure?”
Kyle: “Yes!”
Cartman: “Are you HIV-positive?”*punches Cartman in the face*
…and yes I do hate myself for finding this funny.